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Any Experience With Periactin (Cyproheptadine) For Migraine?


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#1 penguin

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Posted 18 March 2011 - 10:01 PM

I am wondering if anyone has had experience with using Periactin (cyproheptadine) as a migraine preventive med? My doc just prescribed it. It's an old-fashioned antihistamine used more often in kids than adults to help prevent migraine. I am no expert, but I'm told it also reduces serotonin in the brain, which is a bit concerning to me 'cause I'm already depressed, and wouldn't this cancel out an antidepressant med? I'm experimenting with Effexor to see if I can tolerate it and to see if it will or won't exacerbate my migraines. I know there are different serotonin receptors in the brain .... can you tell I like to think too much about this stuff??
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#2 penguin

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Posted 20 March 2011 - 10:52 AM

I am wondering if anyone has had experience with using Periactin (cyproheptadine) as a migraine preventive med? My doc just prescribed it. It's an old-fashioned antihistamine used more often in kids than adults to help prevent migraine. I am no expert, but I'm told it also reduces serotonin in the brain, which is a bit concerning to me 'cause I'm already depressed, and wouldn't this cancel out an antidepressant med? I'm experimenting with Effexor to see if I can tolerate it and to see if it will or won't exacerbate my migraines. I know there are different serotonin receptors in the brain .... can you tell I like to think too much about this stuff??


Reporting in 3 days later: I am amazed at how much this med has helped my head!!! It stopped my brain zaps from Cymbalta disconuation cold, and I have not had a headache of any kind for 3 days now. This is after horrible headaches and migraines (different from one another) for 6 months, every single day. And this, from an old-fashioned antihistamine! The only time I have had a headache in the last 3 days is when I take a tiny dose of Effexor to see if I can tolerate it. I guess not. Highly recommend.
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