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The Lowest Effective Dosage Of Zoloft


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#1 In_Remission_complicatedorsimple

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Posted 03 October 2010 - 04:59 PM

Has anyone's depressed mood lifted on only 25 mg of Zoloft?



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#2 VAL

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Posted 03 October 2010 - 08:19 PM

I suppose that anything is possible but at that dose any response would probably be a placebo response...but again, anything is possible and some people are extremely reactive to even low dosages of meds.
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Past Meds: Siniquan, Elavil, Imipramine, Zoloft, Seroquel, Abilify, Nardil, Emsam, Rozerem, Celexa and Ambien
Current Non-psych: Soma 350mg PRN, Norco 10mg/325 PRN, Percocet 10mg/325 PRN, Advair, Nasonex, Ventolin PRN, Allegra, Benicar, Dexilant, Levothroxine, Pravachol and Nexium. 


#3 cheeker101

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Posted 03 October 2010 - 09:15 PM

25mg is usually only used for panic attacks.
Diagnoses (Past only):
MDD, OCD, GAD, SAnD, PTSD, SSRI/drug induced bipolar II.

Med Experience:
AD: Lexapro, Celexa, Zoloft, Prozac, Wellbutrin, Elavil, Trazadone
AT: Seroquel, Risperdal, Zyprexa, Abilify, Geodon
AED/Benzo: Depakote, Nuerontin, Lamictal, Klonapin, Xanax, Ativan
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#4 cvoor

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Posted 04 October 2010 - 09:19 AM

50 mg is usually the therapeudic dose. 25 did not do much for me at all.
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#5 VAL

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Posted 04 October 2010 - 12:30 PM

I ended up at 200mg which I believe is the highest dose.
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Current Meds: Lamictal 300mg, Wellbutrin XL 450mg, Neurontin 900mg, Klonopin 1.5mg,  Trazodone up to 300mg and Inderal 20mg PRN
Past Meds: Siniquan, Elavil, Imipramine, Zoloft, Seroquel, Abilify, Nardil, Emsam, Rozerem, Celexa and Ambien
Current Non-psych: Soma 350mg PRN, Norco 10mg/325 PRN, Percocet 10mg/325 PRN, Advair, Nasonex, Ventolin PRN, Allegra, Benicar, Dexilant, Levothroxine, Pravachol and Nexium. 


#6 Classically_James

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Posted 21 December 2010 - 05:41 PM

My mother takes 25 mg and does really well on it. However, that dose is more effective for anxiety. I wouldn't do less than 50 for depression.

James
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Diagnoses:

1. Major Depressive Disorder (MDD - atypical type)

2. Seasonal Affective Disorder (SAD)

3. Borderline Personality Disorder (BPD)(in partial remission)

4. Cotard's Delusion (removed prior to DSM IV in 1994(in partial remission)  

 

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1  Luvox (fluvoxamine) 100 mg BID 

2. Abilify (aripiprazole) 10 mg QAM 

3. Forfivo XL (bupropion) 450 QAM

4. Seroquel (quetiapine) 100 mg QHS

5. Xanax (alprazolam) 2 mg TID

6. Desyrel  (trazodone) 150 mg QHS 

7. Lunesta (eszopiclone) 3 mg QHS

8. Soma (carisoprodol) 350 mg TID


#7 Mr_West

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Posted 21 December 2010 - 10:28 PM

Has anyone's depressed mood lifted on only 25 mg of Zoloft?


It has probably happened. 50mg is where most people will get most of Zoloft's SSRI action completely realized. There are probably people who won't need that much SSRI action and will do great at 25mg. Other people need to take Zoloft at higher doses so it hit still more receptors.
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#8 mr2011ez

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Posted 25 December 2010 - 12:23 PM

I am currently taking 50mg of Zoloft (Lupin generic). Initially I was cautious about taking any SSRI class med due to my bad experience with Prozac. But I also take 250-500mg of Depakote (generic) and that seems to prevent any unwanted mood swings. The usual recommended dose for Zoloft used as an AD is 50mg. Then if that doesn't seem to do anything, it may take a dosage increase before the drug kicks in and does its thing. Many things have to be considered when figuring out the correct and effective dosages of any single or psych med combo. I believe this is where the real art and science of bio-psychiatry begins to work in treating a patient successfully. Thanks ez

Edited by mr2011ez, 25 December 2010 - 12:24 PM.

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#9 jenn-rn

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Posted 09 November 2011 - 09:26 AM

I take 6mg of Zoloft and do quite well. It's really an individual thing.
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#10 Revan

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Posted 25 November 2011 - 06:00 PM

^
Yeah, it's a very individual thing. A long time ago I was on 12.5mg and even that was way too stimulating for me.

Edited by Revan, 25 November 2011 - 06:01 PM.

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#11 coatbutton

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Posted 21 January 2012 - 03:30 PM

I was good on 50 mg for a long time, but now I take 100 mg. It is individual. If you know yourself to respond strongly to meds, you could certainly try it.
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#12 BabyBumbleBee

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Posted 22 February 2012 - 06:25 AM

I am on 25mg. Working fine for me, I am weening off. Can't complan about the placebo effect if it is working!
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#13 DancingQueen1918

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Posted 01 April 2012 - 07:51 AM

It started working for me at 50 and was most effective at 75.
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#14 dolly

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Posted 17 April 2012 - 10:07 AM

I spent over 2 weeks on 25mg, it definitely helped with the panic attacks but didn't touch the depression. I'm on 50mg now and can see that the depression is starting to lift a bit - I exercised the past 3 days and am showing a little more interest in things. My Dr. thinks I should be on 100mg but I want to do this slowly to avoid apathy. Apathy just sucks.
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Dolly
Dx: Severe PD, GAD, OCD; depression that comes and goes
Currently prescribed Buspirone 7.5mg 2X/day, Alprazolam 1mg, Zolpidem controlled release 12.5mg; also on Yasmin BCP for PMDD.
Past meds: Venlafaxine 150mg, Citalopram 30mg, Duloxetine 60mg, Escitalopram 10mg, Paroxetine 20mg, Sertraline 100mg Lorazepam 2mg, Klonazepam 1mg, Temazepam 30mg.
18 years on and off meds for brain cooties... this is getting old

#15 Simba Cub

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Posted 18 April 2012 - 12:56 PM

50mg is the usual starting dose; 200mg is the maximum outpatient dose. Therapy wise, I've certainly heard of 25mg paying off.



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#16 ANewLife

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Posted 02 June 2012 - 02:26 PM

I just switched from Paxil to Zoloft today. Hopefully i will fine something soon (ish). Hope things are working well for you!
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#17 Olive

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Posted 02 June 2012 - 03:58 PM

I was on 50mg and during that time went manic.

#18 gilmourr

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Posted 12 June 2012 - 04:49 PM

I'm pretty sure that 50 mg worked for my depression. I remember when I started it that I felt good and I felt no different going up to 200 mg. I'm actually restarting zoloft and am on 50 mg (day 2).
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#19 Abnormal_in_seattle

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Posted 04 September 2012 - 08:11 AM

I am on 150 Mg, and I am still slowly working my way up. I did not notice any difference until I starting hitting 100 Mg
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Current Meds: Depakote 750Mg (q.h.s), Remron 7.5Mg (q.h.s)

 

No Bueno Meds: Fluoxetine, Celexa, Escitalopram, Xanex, Cyclobenzoprin, Methocarbamol, Valium, Zolpidem,Trazodone, Lamotrigine, Depakote, Remron.


#20 Revan

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Posted 25 September 2012 - 07:51 PM

25 mg of zoloft caused a noticeable antidepressant effect within 12 hours after taking it. I had to go down to 12.5mg and even that was too strong for me. It caused anxiety and racing thoughts even at the 12.5mg dose.
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#21 talene

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Posted 26 September 2012 - 11:45 AM

The first time I was on zoloft, I started on 25mg for two weeks and then moved up to 50mg. I noticed some positive effects during the second week (while I was still on 25), but the real benefits didn't come until I moved up to 50. This time, I just started at 50 from the beginning. As far as my depression goes, I could probably stand an increase in dose, but I find it very activating and I'm afraid that if I bump up the dose I'll just get too anxious.
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#22 notfred

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Posted 26 September 2012 - 06:30 PM

Given that the range of doses that are effective varies highly among people, as evidenced my this thread, I don't understand the validity of asking what is the lowest effective dose. There isn't one, it is up to each individual to discover that dose for themselves. The minimum effective dose it the one that works for you, not what works for someone else.
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I am in full remission (296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Abilify 15 mg, (Aripiprazole), Eszopiclone 6 mg (Lunesta), Vyvance 70 mg, (Dextroamphetamine) Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal)
PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal), Ondansetron 8 mg (Zofran)

Supps: Multi-vitamin/mineral, Vitamin D-3 2,000 IU, Omega-3-acid ethyl esters 4 g (Lovaza), Fish oil 1-4 g.

Dx: Depression, Insomnia, ADHD-PI, Epilepsy, Dyspraxia, Tremor

I also take allergy and diabetes + it's complications meds.

All doses are a daily total.


#23 ZenDogs2

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Posted 02 October 2012 - 11:17 AM

After the nightmare of trying out Pristiq, I returned to zoloft after a severe panic attack that sent me to the ER. 50mg of zoloft a day seems to work very well. 25mg just isn't strong enough to control my anxiety & panic. I'm hoping I won't have to increase the dose later on.
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#24 Simba Cub

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Posted 02 October 2012 - 11:28 AM

I guess YMMV - thre is truth to the phrase, trust me! I was on 200mg with little to no improvement whilst some people feel a huge impact on as little as 12.5mg. Depends on the grey goop in your head I guess!



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#25 valentine

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Posted 09 December 2012 - 07:22 AM

I started on 25mg and it is working / having a lifting effect. I'm not increasing unless i need to.

Edited by valentine, 09 December 2012 - 08:15 AM.

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#26 laursmd

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Posted 26 December 2012 - 08:20 AM

25 mgs def knocked out any irritability to be sure but I really need to be on at least 100 and a mood stabilizer for good measure.

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dx: who the f knows? I've been told BP II or Persistent Depressive D/O with MDD.  Everyone agrees on PTSD and possible OCD, RLS, essential hypertension, severe seasonal allergies, asthma
ncurrent rx: Lamictal 150 mg, Brintellix 10 mg, Remeron 15 mg, Klonopin 0.25 mg QAM, 0.5 mg QHS, Requip 0.5 mg Diovan HCT 160/25 mg, Amlodipine 5 mg, Pulmicort 180 mcg 2 puffs BID, Albuterol sulfate 2 puffs PRN, Xyzal 5 mg, Azelastine 1 gtt each eye BID, Patanase 2 squirts each nare BID, Nasonex 2 squirts each nare QHS, Vit D 2000 IU, Omega 3,6,9, Calcium, Magnesium, prenatal vitamin, and the oddest of odd 12-24 oz coconut water daily the week of the full moon (something about water-lyte balance in the brain, and soon to star immunotherapy for my allergies
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#27 shellsbells83

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Posted 16 June 2013 - 11:06 PM

I'm on 25 mg and it works really well. I'm pretty small (115 lbs) and have never been on meds before so my doc wanted to start low. I felt kind of high for the first 2 weeks, but after that I felt like a new person :) Everyone's body processes medicine differently. 


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#28 BelleJar

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Posted 17 June 2013 - 06:48 AM

Yes- 25 mg was the highest I went on zoloft. Any more was very sedating for me. Everyone is different. My psychiatrist has told me that although most people need more, there are many people who are more sensitive. Since we aren't even exactly sure how these medicines work, it is not out of the realm of possibility that they work differently for every person, and in different dosages.
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#29 modestman240

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Posted 17 June 2013 - 01:54 PM

I'm at 100 MG but something tells me 50 would do just about the same.


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Current psych Meds: Zoloft 100MG, Clonazepam 1MG (3 times daily), Lorazepam 2MG PRN, Mirtazepine 15MG

 

 

Previous AD's: Celexa, Lexapro, Effexor XR, Cymbalta,Sertraline

Previous Benzos & Anxiolytics: Lorazepam, Alprazolam, Buspar

AAPS: Seroquel XR, Rispidone,Abilify

 

 

Gradually, then suddenly.' That's how depression hits. You wake up one morning, afraid that you're gonna live.

 

 



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