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Prozac Weakest Ssri


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5 replies to this topic

#1 catman1981

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Posted 26 August 2010 - 01:24 PM

is this true? That it is the weakest ssri thats why they perscribe it to kids? it worked for me at first but sure as hell is not working as good as when i started it!!!



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#2 Artemisia

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Posted 26 August 2010 - 01:50 PM

They prescribe it to kids because it stays in your body for a while, so you don't get withdrawal symptoms after skipping one day (because kids are expected to be irresponsible when taking medications). It's also been on the market the longest--and seems safe--so that helps as well.

It's not the most selective (toward serotonin) of the SSRIs. I'm not sure how one would go about precisely quantifying its strength. The newer SSRIs were developed partly to try to avoid some of the side effects of Prozac. The side effects are pretty individual, though, so there are no firm guarantees....


Edit: You should probably talk to your prescriber about increasing the dose (if that's safe to do), augmenting it with something, or (especially if you haven't been on a lot of antidepressants) switching to something else.

Edited by Artemisia, 26 August 2010 - 02:45 PM.

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#3 Blue Heron

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Posted 26 August 2010 - 02:25 PM

catman, antidepressants as a class are notorious for pooping out on you after a while. It's not just Prozac that often grows less effective as time goes on.
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#4 Kurgan

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Posted 08 November 2010 - 11:46 AM

In the clinic strength and weakness is judged by efficacy: how well the drug does. Prozac is not the weakest.

In terms of selectivity and blocking serotonin reuptake, it is the weakest. It also has a very long half life.

In terms of how well it can work for you, it is by no means weak.

Paroxetine is the "strongest" SSRI, but is it the strongest in a clinical sense? Not for depression.

Edited by Kurgan, 08 November 2010 - 11:46 AM.

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400mg of lamotrigine really hit the spot for depressive symptoms.

Mirtazapine was the icing on the cake.

I am both crazy in the psych and neuro departments btw. No seizures though.

#5 Kurgan

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Posted 08 November 2010 - 11:49 AM

Upping the dose is the logical next step if it has worked for you. You can go very high with Prozac.

I have been up to 120mg (as prescribed by my psych; not me screwing around).
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400mg of lamotrigine really hit the spot for depressive symptoms.

Mirtazapine was the icing on the cake.

I am both crazy in the psych and neuro departments btw. No seizures though.

#6 creepy

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Posted 08 November 2010 - 12:08 PM

I wouldnt say prozac was a weak AD. That award probably belongs to trazodone.
Prozac hits a bunch of stuff other than serotonin. And some people claim it increases their pain level and messes with their blood sugar.
Some of the things its approved for kind of make me wonder. I got really angry and irritable on it. =(
If it was me, I wouldnt go looking for the strongest SSRI. Id make a list of all the choices in that class and what their potential side effects are, and I would try them in order of perceived risk versus benefit.
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