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Alternatives To St Johns Wort


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#1 CaptainYaar

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Posted 26 February 2009 - 09:04 PM

I currently take Effexor XR 75mg for depression and anxiety and I find it affective except for one thing. The med peters out after I would say 8 to 12 hours each day, and since I take it early in the morning, I start freaking out in the evenings with panic attacks and severe depression. My Dr suggested taking it in the afternoons but I really need it for when I work. I asked my Dr if I could take St John's Wort to tide me over in the evenings, but he discouraged it, because it can affetc your blood levels in many different ways (seratonin, etc). I am trying to be compliant to what my Dr says.

My question is: are there any alternatives to St Johns Wort for depression and anxiety that I can take while I am on conventional antidepressants?
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#2 dymphna

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Posted 27 February 2009 - 01:29 AM

Bad idea. SJW is not standardized in the US, so the levels would not be consistent.

A better idea would be to see about getting another, 25mg prescription for the afternoon (which would raise your total dose by 25mg), or getting a completely new script for 37.5mg that you could take twice a day (75mg total).

Personally, I would think that the "add 25mg" would work better, as it appears your body is processing the 75mg pretty completely. Ask your Pdoc.


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#3 CaptainYaar

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Posted 27 February 2009 - 12:26 PM

I am not interested in being on Saint Johns Wort as I know that it can really mess things up. I think I should also mention that I am not on conventional Effexor, but Effexor XR, so the dosing and mechanism may be a bit different than regular Effexor.

Bad idea. SJW is not standardized in the US, so the levels would not be consistent.

A better idea would be to see about getting another, 25mg prescription for the afternoon (which would raise your total dose by 25mg), or getting a completely new script for 37.5mg that you could take twice a day (75mg total).

Personally, I would think that the "add 25mg" would work better, as it appears your body is processing the 75mg pretty completely. Ask your Pdoc.


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#4 dymphna

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Posted 27 February 2009 - 01:08 PM

Then you might be able to tolerate Omega 3s. Read the section on the main page to see what aspects are important. And recognize that they have the potential to flip a person into mania (as do all ADs - for people with and w/o BP).


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#5 Mr_West

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Posted 27 February 2009 - 03:44 PM

You can take two Effexor XR tablets at different times during the day. Even with the extended release Effexor's dismal half life isn't improved.

If twice a day still doesn't provide effective relief consider prozac. It will take longer to kick in, but once it kicks, it kicks.
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#6 In_Remission_euphoria

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Posted 29 May 2009 - 06:23 AM

Rhodiola rosea. SAMe. Kava. The list is pretty much endless.

#7 Jerod Poore

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Posted 29 May 2009 - 10:09 AM

I currently take Effexor XR 75mg for depression and anxiety and I find it affective except for one thing. The med peters out after I would say 8 to 12 hours each day,


You know how everyone bitches about side effects because they are "so med sensitive" and they're poor metabolizers? The second part is often true, as 7 to 15% (depending on study) of Caucasians, 5-7% of Asians and 1-2% of Africans (don't know about mutts, Hispanics or various indigenous groups) have lazy-ass livers. My liver sucks so hard with CYP2D6 meds I was taking half of a 2.5mg Abilify every other day and it not only worked great it still fucked with me.

On the flip side one to two percent of Caucasians are rapid metabolizers (don't have good numbers for anyone else except Ethiopians, where it can be up to 26%). People who burn through meds faster then expected. Way faster. People who don't get a lot of the 'body' side effects like nausea or acne, or they aren't as bad. People with a history of drugs that seem to almost work.

Or drugs that are supposed to work all day don't. Especially something like Effexor that has an active metabolite and goes through several iterations of metabolism.

Talk to your doc about taking the XR version twice a day. 75mg in the morning and 37.5 later or 37.5mg twice a day or something. Omega 3 fish oil? Sure, why not. Other than its own side effects (taste, expense, fishy burbs, low blood pressure) I've yet to come across a bad drug-drug interaction. But I think some kind of twice a day regimen would work best.

Hell, you'd probably need to take Pristiq three times a day! ;)
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