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Wellbutrin And Sleep Erections


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#1 anonymous

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Posted 06 February 2009 - 12:27 PM

For awhile I have been getting very strong erections throughout my sleep, sometimes they go on for so long they get painful and I wake up. I am thinking the wellbutrin might be the culprit? Anyone else have this issue?
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#2 Pillboxfox

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Posted 06 February 2009 - 01:16 PM

Do you take anything else besides Wellbutrin? Trazodone is well known to cause a never ending hard on (priapism). I don't know if Wellbutrin can do that. Maybe.

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Previously tried: Seroquel, Risperdal, Nozinan (levopromazine), Depakote, Lamictal, Effexor, Serzone, Trazodone, Celexa, Wellbutrin, Klonopin, Ativan, Restoril, Serax, Valium

#3 notfred

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Posted 06 February 2009 - 01:25 PM

If it hurts get it checked out.

nf

Edited by notfred, 06 February 2009 - 01:27 PM.

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I am in full remission (296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Abilify 15 mg, (Aripiprazole), Eszopiclone 6 mg (Lunesta), Vyvance 70 mg, (dextroamphetamine) Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal)
PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal)

Supps: Multi-vitamin/mineral, Vitamin D 2,000 IU, Fish oil 7.2 g

Dx: Depression, Insomnia, ADHD-PI, Epilepsy, Dyspraxia, Tremor

I also take allergy and diabetes + it's complications meds.

All doses are a daily total.


#4 anonymous

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Posted 07 February 2009 - 03:01 PM

I checked on line, it is a know side effect but a rare one... this is disappointing, because in all other ways WB is working really well for me...
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#5 In_Remission_atowinram

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Posted 09 February 2009 - 12:41 AM

Definitely check with the doc on it...perhaps taking it at a different time of day would help.

#6 anonymous

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Posted 09 February 2009 - 09:35 PM

Definitely check with the doc on it...perhaps taking it at a different time of day would help.


Saw the pdoc today, he said the benefits outweigh the risks... he said if it happens again and I can't get it under control to go to the ER.
I thinks that as each day passes the risk of it happening again becomes more and more unlikely...


Wish me luck, I was sore for 2 days after that episode...
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#7 anonymous

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Posted 11 February 2009 - 01:12 PM

Well I had another priapism episode last night. I woke up in the middle of the night with an erection I went to the bathroom and ran cold water on my hands to get back to a flaccid state, what scared me is that I don't know how long I was erect. When I woke up in the morning same thing. I also can't figure out why this only happens in my sleep. I have been flaccid since waking up, but now my penis feels very sore.

I hate to stop the WB300xl, it's been working really well for me on all other levels. I didn't notice this problem when I was on 150mg, but after a few weeks 150mg wasn't very effective.

I have a call into my pdoc, any ideas on something that will help with the soreness?
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#8 Anna

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Posted 11 February 2009 - 01:41 PM

Well I had another priapism episode last night. I woke up in the middle of the night with an erection I went to the bathroom and ran cold water on my hands to get back to a flaccid state, what scared me is that I don't know how long I was erect. When I woke up in the morning same thing. I also can't figure out why this only happens in my sleep. I have been flaccid since waking up, but now my penis feels very sore.

I hate to stop the WB300xl, it's been working really well for me on all other levels. I didn't notice this problem when I was on 150mg, but after a few weeks 150mg wasn't very effective.

I have a call into my pdoc, any ideas on something that will help with the soreness?


Well, if WB is the bomb, you might try dropping it to 150 and trying to augment it with something.

Or try 200 m.g. 250 m.g.? Creeping up really slowly to see what happens...It comes in 100 mg tablets.

One winter, my WB was augmented with thyroid hormone. It did seem to increase the efficacy without having to push the dose... keep in mind, though, augmenting with thyroid is still pretty controversial. There are pros and cons.

The problem is, the priapism thing can have serious, lasting effects on your penis if it keeps up. (No pun intended.) Ones I don't think you want to have happen... If I had a penis and that side effect, I'd be pretty hesitant to continue the WB, personally.

Maybe you could try a strattera/provigil combo? That should hit the same neurotransmitters... I think? (Please, someone, correct me if I'm wrong...)

Or try hitting everything with cymbalta or effexor...? If you can tolerate having your serotonin hit at all...

Anna
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#9 notfred

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Posted 11 February 2009 - 01:42 PM

"Medical advice should be sought immediately for cases of erection beyond four hours. Generally, this is done at an emergency department. The therapy at this stage is to aspirate blood from the corpus cavernosum under local anaesthetic. If this is still insufficient, then intra-cavernosal injections of phenylephrine are administered."

http://en.wikipedia.org/wiki/Priapism

This sounds pretty heavy duty, if you need to go to the ER. Erections beyond 4 hours risk damage of the erectile tissue leading to impotence.

Are you taking 300 once a day or 150 twice a day ? Breaking up the dose might help.

nf
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I am in full remission (296.36) from Depression. Insomnia, ADHD-PI, Epilepsy, and the Pseudoparkinsonian tremor are well controlled.

 

Psyc Meds: Forfivo XL 450 mg (Wellbutrin XL), Abilify 15 mg, (Aripiprazole), Eszopiclone 6 mg (Lunesta), Vyvance 70 mg, (dextroamphetamine) Levetiracetam 2,000 mg (Keppra), Propranolol ER 60 mg (Inderal)
PRN: Lorazepam 1-4 mg (Ativan), Alprazolam 1-2 mg (Xanax), Dextroamphetamine 10-40 mg (Dexedrine), Propranolol 20-40 mg (Inderal)

Supps: Multi-vitamin/mineral, Vitamin D 2,000 IU, Fish oil 7.2 g

Dx: Depression, Insomnia, ADHD-PI, Epilepsy, Dyspraxia, Tremor

I also take allergy and diabetes + it's complications meds.

All doses are a daily total.


#10 anonymous

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Posted 11 February 2009 - 02:08 PM

Well I had another priapism episode last night. I woke up in the middle of the night with an erection I went to the bathroom and ran cold water on my hands to get back to a flaccid state, what scared me is that I don't know how long I was erect. When I woke up in the morning same thing. I also can't figure out why this only happens in my sleep. I have been flaccid since waking up, but now my penis feels very sore.

I hate to stop the WB300xl, it's been working really well for me on all other levels. I didn't notice this problem when I was on 150mg, but after a few weeks 150mg wasn't very effective.

I have a call into my pdoc, any ideas on something that will help with the soreness?


Well, if WB is the bomb, you might try dropping it to 150 and trying to augment it with something.

Or try 200 m.g. 250 m.g.? Creeping up really slowly to see what happens...It comes in 100 mg tablets.

One winter, my WB was augmented with thyroid hormone. It did seem to increase the efficacy without having to push the dose... keep in mind, though, augmenting with thyroid is still pretty controversial. There are pros and cons.

The problem is, the priapism thing can have serious, lasting effects on your penis if it keeps up. (No pun intended.) Ones I don't think you want to have happen... If I had a penis and that side effect, I'd be pretty hesitant to continue the WB, personally.

Maybe you could try a strattera/provigil combo? That should hit the same neurotransmitters... I think? (Please, someone, correct me if I'm wrong...)

Or try hitting everything with cymbalta or effexor...? If you can tolerate having your serotonin hit at all...

Anna


I have tried 3 SSRIs in the past all of them made my depression worse, with many other intolerable side effects
Is there something similar to WB that works on dopamine?
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#11 anonymous

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Posted 11 February 2009 - 02:13 PM

"Medical advice should be sought immediately for cases of erection beyond four hours. Generally, this is done at an emergency department. The therapy at this stage is to aspirate blood from the corpus cavernosum under local anaesthetic. If this is still insufficient, then intra-cavernosal injections of phenylephrine are administered."

http://en.wikipedia.org/wiki/Priapism

This sounds pretty heavy duty, if you need to go to the ER. Erections beyond 4 hours risk damage of the erectile tissue leading to impotence.

Are you taking 300 once a day or 150 twice a day ? Breaking up the dose might help.

nf


Yup I have read the details, I don't know how long I am erect because it only happens when I am asleep. As soon as I wake up I can get it back down with running cold water on my hands. I noticed I was having erections in the morning at 150xl once a day. But no pain discomfort, etc. This got more serious when I bumped up to 300xl once a day.

pdoc told me to take a day off from it then go back to 150xl and see how that goes.

with all that being said, my penis feels sore in its' flaccid state, any ideas on how I can sooth the pain?
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#12 martasi2

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Posted 11 February 2009 - 03:36 PM

Go for a urology consult ASAP. It doesn't sound like your Pdoc is aware of the potential for permanent damage, and a urologist should be able to tell you what's causing this symptom. Your Pdoc may be so jazzed about your otherwise positive response to this med he may not care (or know) enough to advise you. You're the guinea pig, in other words, and are risking a lot to prove someone else's point. There are plenty of other meds on the market.

The fact that you're experiencing pain is enough to question continued use of this med. Rather than seek home remedies on a web site, consult a professional (urologist) to see what's causing this.

Edited by martasi2, 11 February 2009 - 03:43 PM.

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#13 anonymous

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Posted 11 February 2009 - 07:02 PM

Go for a urology consult ASAP. It doesn't sound like your Pdoc is aware of the potential for permanent damage, and a urologist should be able to tell you what's causing this symptom. Your Pdoc may be so jazzed about your otherwise positive response to this med he may not care (or know) enough to advise you. You're the guinea pig, in other words, and are risking a lot to prove someone else's point. There are plenty of other meds on the market.

The fact that you're experiencing pain is enough to question continued use of this med. Rather than seek home remedies on a web site, consult a professional (urologist) to see what's causing this.


Yup I just woke up from a nap and once again as hard as could be, I already took my 300xl dose today
so I am not looking forward to sleeping anymore
I think I will set the alarm for every hour to check if I am ok
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#14 Stacia

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Posted 11 February 2009 - 08:23 PM

Mirapex is a Parkinson's med that works on Dopamine. It's generally not as powerful as WB and I think it's mechanics are different. Treating depression is an off label use.

I haven't really been on WB to compare, but I know that Mirapex works really well for me.


Yeh, I wouldn't mess with the priapism. Hopefully, it's not an issue tonight.
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#15 anonymous

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Posted 11 February 2009 - 10:30 PM

Mirapex is a Parkinson's med that works on Dopamine. It's generally not as powerful as WB and I think it's mechanics are different. Treating depression is an off label use.

I haven't really been on WB to compare, but I know that Mirapex works really well for me.


Yeh, I wouldn't mess with the priapism. Hopefully, it's not an issue tonight.


yeah I am gonna take my pdocs advice, and skip the WB tomorrow then go back to 150xl I didn't have problems at the 150 dose.
I am also going to call my urologist tomorrow and get checked out.

This really sucks, cuz wb was just perfect for me, I felt completely normal, and didn't feel like I was on anything.
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#16 anonymous

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Posted 13 February 2009 - 10:24 AM

Urologist said no major damage done.
Yesterday I didn't take any WB
and last night I woke up 6 times with erections
I wonder how long this is going to take to pass.
I guess no WB for me today either
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#17 Jerod Poore

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Posted 13 February 2009 - 12:35 PM

Urologist said no major damage done.


That's good. You do realize that for everyone else this can seem like an extremely humorous situation, right? Humor = tragedy happening to other people. It's a shame the topic about the side effect of porno boobs was lost with version 8 of this forum.

I wonder how long this is going to take to pass.


Given the triple metabolism involved that's hard difficult to pin down. Some of those metabolites might be active, and what they all do isn't really known.

As Stacia mentioned Mirapex is used as a substitute, as is Requip, the other popular Parkinson's / RLS med. A better substitute would be selegiline, which is approved for depression. Like Wellbutrin selegiline (the Emsam patch or Eldepryl tablets) also has a positive affect on norepinephrine. Mirapex and Requip don't do much, if anything, for norepinephrine.

I guess I can lump Wellbutrin in with trazodone in that Bob Dole didn't need Viagra to beat Bill Clinton, Bob Dole needed Wellbutrin.
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#18 anonymous

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Posted 13 February 2009 - 01:55 PM

Is there anything else out there that works on dopamine as well at WB?
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#19 anonymous

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Posted 13 February 2009 - 05:09 PM

http://www.medhelp.o...ages/31430.html

seems like I am not the only one with this problem...
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#20 RinconJohn

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Posted 18 February 2009 - 11:35 AM

Hey anonymous, you do know it's normal to have many erections during the sleep cycle? I've noticed that sometimes they can be so full and sustained that they are uncomfortable; I think this too, is normal. Of course, if they are making you sore on a regular basis then that is definitely not normal.

Is urination playing any role? A full bladder puts pressure on nerves that can cause erection and a frustrating situation!

Hope you can definitely avoid the ER. "Aspirating blood" does not sound like a very appealing procedure. Yucky way to make a blood donation. . . :mad:
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#21 anonymous

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Posted 18 February 2009 - 11:05 PM

Hey anonymous, you do know it's normal to have many erections during the sleep cycle? I've noticed that sometimes they can be so full and sustained that they are uncomfortable; I think this too, is normal. Of course, if they are making you sore on a regular basis then that is definitely not normal.

Is urination playing any role? A full bladder puts pressure on nerves that can cause erection and a frustrating situation!

Hope you can definitely avoid the ER. "Aspirating blood" does not sound like a very appealing procedure. Yucky way to make a blood donation. . . :mad:


These were pretty bad, it felt like I was going to burst open any min. I have been off WB for 6 days now, and I still am having painful erections at night.
I put in a 2nd call to my urologist, hopefully he gets back to me soon. my pdoc said that the WB should be completely out of my system by now.

my guess is that what I am having now is just normal nocturnal erections but the tissues are sore and swollen and all erections are going to hurt now, until it has time to heal up...

what a mess, going to see the pdoc on monday, and try something else...

are there any other anti-depressants that have a weight loss side effect besides wb?
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#22 anonymous

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Posted 03 March 2009 - 04:41 AM

I also take 1000mg of slow release niacin, I am wondering if that combined with the WB may have been a contributing factor leading to priapism?
My cardio doc has me on the niacin, it's suppose to do something good for my cholesterol, I know it also expands your capillaries too.

Anybody know if I am on to something?
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#23 martasi2

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Posted 03 March 2009 - 10:01 AM

Well, if you go to the Mayo Clinic page on Niacin: http://www.mayoclini..._patient-niacin
and scroll way down to the Dosing section, you'll find a paragraph on equivalencies. Niacin is converted to Tryptophan (think serotonin), and your dose of 1,000 milligrams is giving you a fairly good-sized serotonin boost.

Since Serotonin does affect libido and sexual function, there may be a connection. From what I read, 1,000 mg. of Niacin is considered a high-dose that can also cause homocysteine levels to rise. Yes, it can help w/atherosclerosis and dilate blood vessels, so it's no wonder 1,000 mg. may affect blood vessels in this part of your body. Is it damaging your tissues? I'm not a doctor, and can't say. But continuing pain might be another part of the answer. Does your urologist know about the 1,000 mg. of niacin?

But I'd sure ask your cardio why such a high dose and explain the symptoms. You may need to reduce the dose so as not to cause permanent harm to yourself. From what I read, niacin dosing at this range is still experimental. Hope you're not a guinea pig for this dr. too . . .
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#24 anonymous

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Posted 03 March 2009 - 02:00 PM

Well, if you go to the Mayo Clinic page on Niacin: http://www.mayoclini..._patient-niacin
and scroll way down to the Dosing section, you'll find a paragraph on equivalencies. Niacin is converted to Tryptophan (think serotonin), and your dose of 1,000 milligrams is giving you a fairly good-sized serotonin boost.

Since Serotonin does affect libido and sexual function, there may be a connection. From what I read, 1,000 mg. of Niacin is considered a high-dose that can also cause homocysteine levels to rise. Yes, it can help w/atherosclerosis and dilate blood vessels, so it's no wonder 1,000 mg. may affect blood vessels in this part of your body. Is it damaging your tissues? I'm not a doctor, and can't say. But continuing pain might be another part of the answer. Does your urologist know about the 1,000 mg. of niacin?

But I'd sure ask your cardio why such a high dose and explain the symptoms. You may need to reduce the dose so as not to cause permanent harm to yourself. From what I read, niacin dosing at this range is still experimental. Hope you're not a guinea pig for this dr. too . . .


I had stopped taking WBXL when the priapism started, then I gave it a 2nd chance at 150mg instead of 300mg,
so for a week at 150mg no priapism, but I remembered I wasn't taking my niacin during that time, and the first day I went back on niacin the priapism came back. So it may just be coincidental timing but it could be the combination of WB and Niacin is what is doing it.

So my plan is to continue on WB, and stop the niacin, if the priapism doesn't come back then I will try adding niacin back in at 500mg and see how that goes.
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#25 dymphna

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Posted 04 March 2009 - 12:30 AM

I had stopped taking WBXL when the priapism started, then I gave it a 2nd chance at 150mg instead of 300mg,
so for a week at 150mg no priapism, but I remembered I wasn't taking my niacin during that time, and the first day I went back on niacin the priapism came back. So it may just be coincidental timing but it could be the combination of WB and Niacin is what is doing it.

So my plan is to continue on WB, and stop the niacin, if the priapism doesn't come back then I will try adding niacin back in at 500mg and see how that goes.


See... isn't this place awesome? I love it when people figure stuff out like this.


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#26 anonymous

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Posted 04 March 2009 - 12:51 AM

I had stopped taking WBXL when the priapism started, then I gave it a 2nd chance at 150mg instead of 300mg,
so for a week at 150mg no priapism, but I remembered I wasn't taking my niacin during that time, and the first day I went back on niacin the priapism came back. So it may just be coincidental timing but it could be the combination of WB and Niacin is what is doing it.

So my plan is to continue on WB, and stop the niacin, if the priapism doesn't come back then I will try adding niacin back in at 500mg and see how that goes.


See... isn't this place awesome? I love it when people figure stuff out like this.


Dymphna


Well I talked to my pharmacist, he thinks it's impossible for niacin to be the problem.
The priapism came back last night and I have been sore all day... :mad:
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#27 anonymous

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  • Current Meds:Nothing! Cannot tolerate Paxil, Celexia, Cymbalta, or Wellbutrin, what's next?

Posted 04 March 2009 - 04:12 PM

While wellbutrin worked so well for me, the priapism just wont stop, so I have to give up on it,
and SNRIs and SSRIs have intolerable side effects I can't deal with, I feel so hopeless...
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#28 martasi2

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Posted 04 March 2009 - 04:58 PM

While wellbutrin worked so well for me, the priapism just wont stop, so I have to give up on it,
and SNRIs and SSRIs have intolerable side effects I can't deal with, I feel so hopeless...


Look, you're lucky you have such a good, healthy circulatory system. The proof is how well these products "work" for you. If you had bad circulation you'd never feel a thing. You might cut out the niacin for a while and let your body return to its baseline and then go for another med trial and see what happens. Are you taking any other supplements like amino acids or l-arginine or any of that powdered supplement/protein drink stuff you buy at gyms and online?

I have a lot of respect for pharmacists, but I wouldn't let this one have the last word. 1,000 mg. of niacin is way above a standard or even therapeutic dose. Every body is different, and maybe you don't NEED this.

I'm not sure what your specific depression symptoms are, but there are lots of meds on the market that target one biochemical system or another. For one thing, you might have been on too high a dose of all these meds. The niacin might have released too much of the med because your circulatory system is working so well; it might have expedited the action of the drug. Maybe you need an AED med w/an AD. I don't know.

There may be other meds that will work on the depression. The thing to do is talk w/your Pdoc about what has been tried and what hasn't and go from there.

Edited by martasi2, 04 March 2009 - 05:00 PM.

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#29 anonymous

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  • Diagnoses:depression
  • Current Meds:Nothing! Cannot tolerate Paxil, Celexia, Cymbalta, or Wellbutrin, what's next?

Posted 04 March 2009 - 08:08 PM

While wellbutrin worked so well for me, the priapism just wont stop, so I have to give up on it,
and SNRIs and SSRIs have intolerable side effects I can't deal with, I feel so hopeless...


Look, you're lucky you have such a good, healthy circulatory system. The proof is how well these products "work" for you. If you had bad circulation you'd never feel a thing. You might cut out the niacin for a while and let your body return to its baseline and then go for another med trial and see what happens. Are you taking any other supplements like amino acids or l-arginine or any of that powdered supplement/protein drink stuff you buy at gyms and online?

I have a lot of respect for pharmacists, but I wouldn't let this one have the last word. 1,000 mg. of niacin is way above a standard or even therapeutic dose. Every body is different, and maybe you don't NEED this.

I'm not sure what your specific depression symptoms are, but there are lots of meds on the market that target one biochemical system or another. For one thing, you might have been on too high a dose of all these meds. The niacin might have released too much of the med because your circulatory system is working so well; it might have expedited the action of the drug. Maybe you need an AED med w/an AD. I don't know.

There may be other meds that will work on the depression. The thing to do is talk w/your Pdoc about what has been tried and what hasn't and go from there.


Nope not taking any supplements like that, I don't know what an AED or an AD is?

I have tried the following;
Paxil - 1 month and everyday I felt like I wanted to jump out of my skin, bad constipation - no positive benefit for the depression
Celexia - 2 months, also felt like I wanted to jump out of my skin, bad constipation, and acne - no positive benefit for the depression
prozac - 1 month, again wanted to jump out of my skin, bad constipation, couldn't get an erection
cymbalta - 1 day, vomited all day, couldn't hold food down for 36 hours, I felt extreme panic, I never normally feel panic at all
Wellbutrin - a few weeks, worked wonders, my depression was gone, I felt normal, productive, thinking clearly, more self control over my diet. but after 2 weeks of use each time, I would have night time episodes of painful priapism. I can't risk it any longer no matter how well it treats my depression
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#30 martasi2

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Posted 04 March 2009 - 10:33 PM

I have tried the following;
Paxil
Celexia
prozac
Cymbalta
Wellbutrin


You are just getting started. There are so many other meds that might work. Unfortunately, this is sometimes how it is when looking for the best med.
AD = antidepressant
AED = anti-epileptic (anti-seizure) med (sometimes AC for anticonvulsant)

Consider a new post (or read what's already there, I'm not sure) about alternatives to Wellbutrin. Also read the antidepressant list on the crazymeds main page.
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