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Seroquel And Grapefruit


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#1 In_Remission_dizzyfaerie

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Posted 23 April 2008 - 01:54 PM

how bad is it really?
if i eat a grapefruit once in a blue moon is my head gonna explode? :mad:



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#2 lostanddelirious

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Posted 23 April 2008 - 05:18 PM

No it interferes with most meds. Not so significantly. It justs makes it a LITTLE less effective. People with disorders such as seizures need to be more aware and try not to dabble in the grapefruit.
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#3 berry

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Posted 23 April 2008 - 06:34 PM

before i realised this was a problem, i drank grapefruit juice a few times. still alive :mad:
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#4 Jerod Poore

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Posted 25 April 2008 - 10:33 AM

No it interferes with most meds. Not so significantly. It justs makes it a LITTLE less effective.


Not most, but many. Plus grapefruit juice is a potent inhibitor of CYP3A4, which means the drugs involved hang around longer. It's as if you took more, not less. Its effects can last up to three days after the last time you had some.

People with disorders such as seizures need to be more aware and try not to dabble in the grapefruit.


That's true.
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#5 Jerod Poore

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Posted 25 April 2008 - 10:37 AM

how bad is it really?


As I wrote above grapefruit is a potent inhibitor of the enzyme that is used to metabolize Seroquel.


if i eat a grapefruit once in a blue moon is my head gonna explode? :mad:


A single grapefruit won't make a tremendous difference. It will be as if you increased your dosage somewhat for a couple of days, so it's not a good idea.
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Current meds: lamotrigine 300mg, topiramate 325mg, buspirone 60mg, protriptyline 60mg, EPA 600mg, methylphenidate 5-10mg, lorazepam 1mg PRN
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#6 In_Remission_Medicated_Madness

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Posted 14 August 2008 - 06:30 AM

If this is true why do you think I was never informed by a medical professoinal to not eat grapefruit?? I was prescribed 400mg of seroquel at one point.

#7 litgirl

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Posted 14 August 2008 - 08:10 PM

If this is true why do you think I was never informed by a medical professoinal to not eat grapefruit?? I was prescribed 400mg of seroquel at one point.


There wasn't a little sticker on the bottle from the pharmacy about the grapefruit thing? Mine always had a sticker on it or, with some other meds it's in the simplified sheet (the one pager, not the million long one) of major interactions/warnings from the pharmacy that comes with each prescription. I always read that "Important Information" sheet at least, if not the long full prescribing info sheet.

I thought that was pretty standard of pharmacies? No?
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#8 In_Remission_bucket head

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Posted 21 August 2008 - 04:51 PM

Okay....this may sound like a joke but I assure you that it isn't. I started Seroquel yesterday, and today I can't stop drinking Fresca (ingredients: carbonated water, citric acid, grapefruit juice). Kind of forgot that Fresca's grapefruit-based. Strange little coincidence that I'm craving it at this point.

Bye-bye Fresca; hello water. Nevertheless, no unsightly head explosions here.

#9 Peregrine

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Posted 17 May 2009 - 03:38 PM

Thankfully I don't like grapefruit!

One other question, relatedly, is whether the "no grapefruit" warning also applies to Earl Gray tea and other things flavored with bergamot? Various sources seem to imply that the grapefruit issue is due to bergamottins in the grapefruit, in which case Earl Gray might cause problems. Partner's dad is on statins and has been told to not drink Earl Gray as a result, but I've never heard this warning for Seroquel. And, while I don't like Earl Gray (maybe I hate bergamottins?), there is one flavor of it that I'm very fond of.

Thoughts?
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#10 xbmcx

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Posted 23 June 2013 - 03:45 PM

Great, I just had some Fresca and didn't realize that it had grapefruit juice in it until I looked at the label to find out and viola, it does! :( Due to my awareness of its interactions with various drugs, particularly Seroquel, i started freaking out. In laymen's terms I had somewhere read/heard that it inhibits certain enzymes from breaking it down and metabolizing it normally, thus leaving more in the system and for longer. Three times as much? Is that that correct? Do I have anything to worry about? Or is it really going to affect my mood and functioning? I've already been having enough trouble as is, like I need one more thing to throw me off. 


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