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Sodium Valproate Vs Lamictal- Please Help?


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4 replies to this topic

#1 guest1

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  • Current Meds:lexapro 10mg, lamictal 50mg

Posted 19 March 2012 - 01:46 PM

Hi guys,
I am feeling quite distressed at the moment so any help would be greatly appreciated. I have bipolar 2 which was diagnosed 2 years ago and since then I have been really unstable and trying one medication after another.
I did go ok on zyprexa for a while but unfortunately stacked on a huge amount of weight very quickly with it.
Most recently I tried lithium for 6mths but I just kept cycling between weeks of having severe depression and coming up to just below normal.
I had my psychiatrist appointment today and he gave me the option of going onto sodium valproate or lamictal- as I did not know anything about either I let him decide and he went with SV because it is a lot cheaper than lamictal ( here in Australia). When I got home from the appointment I have been madly looking up info on both drugs. And now i am thinking maybe it would be better to try lamotrogine instead of SV.
From what I can see it is better for rapid cycling and better for depression ( I suffer much more from depression) and is also weight neutral.
What do you guys think- should I try the SV or go for the lamotrogine?
I am worried about wasting more time and putting on more weight on SV and I don't mind paying more for the lamotrogine if it possibly is going to work.
many thanks.
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#2 Sweetest1

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  • Current Meds:clonazepam 1.5mg, Wellbutrin 300mg, ativan .5mg prn, Epival/Depakote 1250mg
  • Location:Too close to Vancouver, Canada

Posted 19 March 2012 - 04:16 PM

the Sodium Valproate won't do anything for depression. Lamictal is pretty much the gold standard for bipolar depression. I'd fork out the extra money and go that route instead. Just my opinion, of course.
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I am not a doctor - I am just an !diot.
Nothing I say should be considered as medical advice.
These are merely my personal opinions; of which there is a seemingly inexhaustible supply.


Previous Meds: Zeldox/geodon, risperidone, seroquel, effexor, topamax, lithium, zyprexa, cipralex, trazadone

#3 Her

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  • Current Meds:Seroquel (XR and IR), topiramate, lamotrigine, Ambien CR, escitalopram
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Posted 19 March 2012 - 04:28 PM

Having taken both, I agree with Sweetest1. Depakote left me feeling flat. I was on it for over a year in 2000-2001, during which time I had no manic episodes (I was put on it because I was coming off a doozy), but I didn't feel anything else, either, including happy...ever.

Over the last few years my main problem has really been moderate depression with occasional fairly brief switches to hypomania. If I pay attention, I can nip the hypomanias with increased Seroquel, which just leaves the depression. Lamotrigine has been a miracle for that. Hands down the best med I've ever tried.
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Give us this day our daily meds:150 mgs lamotrigine, 75 mgs topiramate, 150 mgs Seroquel XR, 100 mgs Seroquel IR, 12.5 mgs Ambien CR, 15 mgs escitalopram, 4000 i.u. Vit. D3. Azelastine spray for allergies.

Cyclobenzaprine and Midrin PRN.

Past, failed attempts: Effexor XR, Celexa, amitriptyline, Depakote, Geodon, klonopin, ativan, bupropion, busipirone, lithium, trazodone, Lunesta, Rozerem, gabapentine, mirtazapine, Wellbutrin, Temazepam, Sonata.

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#4 metatrix

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  • Location:Canada

Posted 19 March 2012 - 05:21 PM

Hi guys,
I am feeling quite distressed at the moment so any help would be greatly appreciated. I have bipolar 2 which was diagnosed 2 years ago and since then I have been really unstable and trying one medication after another.
I did go ok on zyprexa for a while but unfortunately stacked on a huge amount of weight very quickly with it.
Most recently I tried lithium for 6mths but I just kept cycling between weeks of having severe depression and coming up to just below normal.
I had my psychiatrist appointment today and he gave me the option of going onto sodium valproate or lamictal- as I did not know anything about either I let him decide and he went with SV because it is a lot cheaper than lamictal ( here in Australia). When I got home from the appointment I have been madly looking up info on both drugs. And now i am thinking maybe it would be better to try lamotrogine instead of SV.
From what I can see it is better for rapid cycling and better for depression ( I suffer much more from depression) and is also weight neutral.
What do you guys think- should I try the SV or go for the lamotrogine?
I am worried about wasting more time and putting on more weight on SV and I don't mind paying more for the lamotrogine if it possibly is going to work.
many thanks.


Lamictal is supposed to be better for bipolar II and depressive symptoms than SV.

But I am on SV and I LOVE it. It has done so much for my anxiety. I used to be such an incredibly anxious person, but I don't feel anxious at all anymore. Also, I haven't had any side effects. From what I've read, lamictal is more likely to cause cognitive side effects than SV. I also haven't had any weight gain or hunger on SV, but technically lamictal is supposed to be more 'weight neutral' than SV. I also do feel much happier (mostly as a result of the decreased anxiety) since starting SV.

Edited by metatrix, 19 March 2012 - 05:23 PM.

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Age: 23; Dx: Bipolar I, ADHD, OCD, Trichotillomania, Tourette's Syndrome, GAD, Social Phobia, Borderline Personality Disorder, Restless Legs Sydrome; Current Meds: Dexamphetamine (Dexedrine SR) 35 mg, Duloxetine (Cymbalta) 60 mg, Aripiprazole (Abilify) 4 mg, Divalproex sodium (Epi-Val/Depakote) 1000 mg; Lorazepam (Ativan) 1 mg prn; Iron Supplements Past Meds: Paroxetine (Paxil), Citalopram (Celexa), Sertraline (Zoloft), Risperidone (Risperdal), Ziprasidone (Zeldox), Amphetamine (Adderall XR), Methylphenidate (Ritalin).

#5 guest1

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Posted 20 March 2012 - 09:21 PM

Thank you guys so much for your replies- it is so wonderful to be able to get feedback and reassurance. I now have enough confidence to contact my psychiatrist with my concerns and hopefully will try lamictal - fingers crossed it works out this time
thanks again!
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