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Mirtazapine Poops Out For Sleep - Really?

mirtazapine sleep

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#1 In_Remission_PandorableApril

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Posted 18 November 2011 - 02:32 PM

Most of what I read about the infamous mirtazapine poop-out appears to be about it no longer working for depression. Anybody have it poop out at low doses for sleep?

I'm asking because I was on 15 mg for about two months, with great sleep. Then my usual wake-up-way-too-early-and-can't-get-back-to-sleep routine came back and hasn't gone away again. I tried lowering the dose to 7.5 and my sleep is about the same. Still helps some with sleep onset, but doesn't keep me sleeping like it used to.


#2 Got the T-shirt

Got the T-shirt

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Posted 19 November 2011 - 12:19 AM

The waking-too-early symptom is a classic early symptom of Depression. Could this be the start of a general 'poop out' of the drug?
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#3 In_Remission_PandorableApril

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Posted 21 November 2011 - 01:33 PM

Hmm, interesting. Somehow I hadn't heard that one before; I figured I just had sleep problems. For the last ~13 years I've awakened too early, except on one medication cocktail which I discontinued because of side effects. I wouldn't be surprised if this was related to depression, though, since I've been making changes in my other meds.

Mirtazapine isn't my primary AD in the cocktail I'm now using, so I'm not terribly concerned about whether this is a harbinger of greater poop-out impending for this med. I am concerned that the primary function of mirtazapine (for me) seems to have ceased working.

But...if it's not depression-related, maybe my histamine response has just changed because of using mirtazapine daily for a few months? Anyone experienced mirtazapine poop-out for sleep, specifically?

~ Jenica

#4 Rainman56


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Posted 29 December 2011 - 07:41 PM

I,m at 60mg and yes for about the last 3 months I,ve noticed a big difference as far as sleep.Even at lower doses about 30 mins later it was lights out.Now while I still sleep I can stay up for quite some time and no real cobwebs,still the food cravings after taking it though.For me it could be the starting of poop out though.Even if it is not to scare ya as everyone is different but the loss of sleepiness was the first thing I noticed.
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Past meds:Zoloft(pooped out after 5 years),Effexor,Luvox,Cymbalta,Pristiq,Remeron(pooped out after 3 years),Paxil/lamictal(2nd go around and pooping out now after 5 months)Abilify,Lexapro,14 Treatments ECT,anafranil


Current meds:Paxil/lamictal Combo(pooping out) so looking for new med.Clonazepam/prn Seroquel/prn

#5 RleeP2


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Posted 03 January 2012 - 02:06 PM

I would imagine everybody's different to some extent with this matter..

Here's how it goes for me (I've been on Mirtazapine at varying doses for about 2 years):

At 15 mg. I was poleaxed and was out like a light within an hour or so of taking it. I didn't have much choice whether I fell asleep or not.

At 30 mg, I got sleepy within an hour of dosing, but could usually ignore it if I was doing something. I'd be foggy, but awake. Then, when I did try to go to sleep, I went right out. The key difference seemed to be that at 30, I had a choice. At 15 mg, I didn't.

At 45 mg, I don't get sleepy, at least not that I can notice. But when I go to bed, I usually fall asleep within 8-10 minutes. But I also wake up sooner and with virtually none of the morning grog/fog I had at 15 mg (especially) or 30 mg.

But at any given time, I can break my 45 mg tab in half and take that and get knocked out pretty much the same as i did at 15 mg, when i first started it. I know this because every now and then, if I'm late taking my Adderall XR and still zipping along on that a bit when bed time comes, I'll take a half a 45 mg Mirtazapine and it puts me right to sleep.,

So, I guess I'd say there is no sleep facilitation poop out for me...
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#6 In_Remission_Xeen

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Posted 20 January 2012 - 03:45 AM

I'm on 30mg and find it doesn't put me to sleep anymore. This happened in the first week of using the drug. Some nights I toss and turn for ages. I do feel sleepy but I can't get to sleep.

#7 3jane


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Posted 22 January 2012 - 06:27 PM

When I took Mirtazapine (sorry, can't remember dose), I would have very restful sleep, complete with vivid dreams, for two or three days and then it'd just.. stop. No tapering off or anything, just a giant transition to awesome sleep to nothing.
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