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Anyone Try Savella For Depression


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#1 In_Remission_depressedanxiety

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Posted 12 March 2011 - 10:07 PM

I have been on almost every type of antidepressamt and have had little success.

Has anyone had any luck with Savella? What side effects have you experienced. I'm on Day 8 and up to 100 mg.



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#2 In_Remission_loonsworld

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Posted 13 March 2011 - 04:37 AM

I was on Milnacipran when it was being trialled here - all i got was hot flushes and a really bad case of erectile dysfunction. After about 2 weeks i was getting manic episodes so it didn't really agree with me.

I hope you have better luck with it than i did. I know that it is being prescribed to treat fibromyalgia as an alternative to Lyrica.

#3 In_Remission_bicrazy

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Posted 26 August 2011 - 09:20 PM

Savella nearly killed me. After the first dose, my blood pressure shot thru the roof (175/100). I stopped taking it immediately. Coincidentally, I had an appointment with my internist the next day. She said my BP was in the 'stroke zone'. I have a BP monitor at home -- it goes around the wrist. Now I had to start taking meds for high BP; it took several months for my BP to return to normal. Now I monitor my BP whenever I go on a new med.

Edited by bicrazy, 26 August 2011 - 09:21 PM.


#4 In_Remission_suivis

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Posted 19 November 2011 - 07:06 PM

I'm coming off of Savella now after having been on it for close to a year. About a month into it, I wasn't in any state to listen to anyone tell me that I was becoming aggressive and unreasonable. I know myself well enough that once I hit rapid cycling (multiple cycles a day), suicidal ideations and hallucinations that I knew I needed to come off the Savella. The warnings say that if you become aggressive, you should talk to your doctor. I was only mildly aggressive at first, didn't hit anyone the entire time I was on it, but there were a lot of rapid cycle emotions with active body language and pacing and anxiety, including anxiety about not being on it. I would always feel better after I would take it. People were telling me that I was being aggressive and that something was wrong, but I was far enough away from everything in my head that I couldn't put together that those were side effects of the medication. I was paranoid that they were attacking choices I made about my life instead. My advice would be to be very careful and have someone that you trust to tell you specifically to talk to your doctor about the medication's side effects if you start to act aggressively.

#5 ScreamingMimi

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Posted 14 January 2012 - 11:36 PM

I took it for a day, I think. It made me horribly aggressive and on top of that, it gave me terrible heartburn all day long. It scared me so bad I quit right then and there.
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#6 mharcais

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Posted 23 June 2012 - 03:23 PM

My doc prescribed Savella after I asked about switching from venlafaxine ER (generic Effexor XR) to Cymbalta; I also am taking cyclobenzaprine (aka Flexeril) for skeleto-muscular disorder and I thought this could mean one less medication. Transition is "complete," although I'm still dealing with the dizziness and light-headedness from discontinuation of the venlafaxine. This is my third day without it, so I hope the symptoms will go away soon. I'm still taking the Flexeril, though, because I'm feeling body aches and pains even while taking it, and I've no wish to make it worse. Knowing that I'm taking Savella off-label isn't increasing my comfort level. This guinea pig will be happy to update. I'm thrillled to be off The Devil Drug (Effexor) for good.
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Diagnosis: Type II bipolar disorder

Current Meds (in daily doses): Pristiq (desvenlafaxine succinate) 100mg; Klonopin (clonazepam) 0.5mg

Past Meds: Serzone (nefazodone HCl); Prozac (fluoxetine hydrochloride); Wellbutrin XL (bupropion hydrochloride); Aplenzin (bupropion hydrobromide); Topamax (topiramate); Effexor XR (venlafaxine HCl); Strattera (atomoxetine HCl), Maprotiline HCl; Provigil; Nuvigil.

It's a wonder I still have a liver.


#7 quiet storm

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Posted 22 July 2013 - 06:02 PM

My doc mentioned savella to me today after discussing about possibly getting back on cymbalta, mainly for headaches, but secondarily for mood. I was a sweaty, jittery mess when I was on it but I got alot of shit done when I was on cymbalta. She mentioned savella and it was the first I've heard of it. Probably because its only approved for fibromyalgia in the US. It's classified as an SNRI but from what I've read it pushes the norepi about 3 times as much as serotonin. Probably why it's good for pain......and the aggressiveness mentioned above. I think I'll stick with cymbalta if it comes down to it. You know, better off with the devil you know....
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#8 Serpens

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Posted 22 July 2013 - 07:16 PM

My doc mentioned savella to me today after discussing about possibly getting back on cymbalta, mainly for headaches, but secondarily for mood. I was a sweaty, jittery mess when I was on it but I got alot of shit done when I was on cymbalta. She mentioned savella and it was the first I've heard of it. Probably because its only approved for fibromyalgia in the US. It's classified as an SNRI but from what I've read it pushes the norepi about 3 times as much as serotonin. Probably why it's good for pain......and the aggressiveness mentioned above. I think I'll stick with cymbalta if it comes down to it. You know, better off with the devil you know....

 

Bit of an outdated thread but there's been some info recently.

 

Forest, in their ongoing quest to abuse the everliving crap out of brand names and the patent system has been trying to get the active enantiomer of Savella (levomilnacipran) approved for depression. Back in 2012 they got a pretty sound thrashing by the FDA over abysmal efficacy in their studies, just really really bad results.

 

It looks like they've re-applied with a new study that shows better results. However, the study isn't as large as it should be: they used very severe depression as an inclusion criteria, using HDRS, SDS, but then used MADRS as a measure of outcome - which is pretty well known to be defective. The FDA CDER response is due out on 7/26.


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#9 mharcais

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Posted 23 July 2013 - 04:40 PM

Following up on my Savella experience.  Short story:  it didn't work.  Didn't take care of the aches and pains and I found myself in the depths of depression the likes of which I hadn't felt in years.  Have transitioned on to Pristiq and finding it working quite well.  Incidently, shortly after transitioning onto Pristiq, my therapist started noticing my cycling and racing thoughts, probably because they were surfacing after the abyss of depression.  Was diagnosed with Type II bipolar disorder and also taking Klonopin.


Edited by mharcais, 23 July 2013 - 04:46 PM.

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Diagnosis: Type II bipolar disorder

Current Meds (in daily doses): Pristiq (desvenlafaxine succinate) 100mg; Klonopin (clonazepam) 0.5mg

Past Meds: Serzone (nefazodone HCl); Prozac (fluoxetine hydrochloride); Wellbutrin XL (bupropion hydrochloride); Aplenzin (bupropion hydrobromide); Topamax (topiramate); Effexor XR (venlafaxine HCl); Strattera (atomoxetine HCl), Maprotiline HCl; Provigil; Nuvigil.

It's a wonder I still have a liver.


#10 quiet storm

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Posted 23 July 2013 - 06:04 PM

Your past meds section is all jacked up. Serzone is not escitalopram. Escitalopram is lexapro. Prozac is not duloxetine. Duloxetine is cymbalta.

Prozac=fluoxetine
Serzone=nefazodone.
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#11 mharcais

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Posted 23 July 2013 - 07:39 PM

Oops.  Must have taken two doses of Klonopin.

 

Thanks for the heads up.  Double-checked everything, as you can see.


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Diagnosis: Type II bipolar disorder

Current Meds (in daily doses): Pristiq (desvenlafaxine succinate) 100mg; Klonopin (clonazepam) 0.5mg

Past Meds: Serzone (nefazodone HCl); Prozac (fluoxetine hydrochloride); Wellbutrin XL (bupropion hydrochloride); Aplenzin (bupropion hydrobromide); Topamax (topiramate); Effexor XR (venlafaxine HCl); Strattera (atomoxetine HCl), Maprotiline HCl; Provigil; Nuvigil.

It's a wonder I still have a liver.


#12 quiet storm

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Posted 04 August 2013 - 06:48 PM

My doc mentioned savella to me today after discussing about possibly getting back on cymbalta, mainly for headaches, but secondarily for mood. I was a sweaty, jittery mess when I was on it but I got alot of shit done when I was on cymbalta. She mentioned savella and it was the first I've heard of it. Probably because its only approved for fibromyalgia in the US. It's classified as an SNRI but from what I've read it pushes the norepi about 3 times as much as serotonin. Probably why it's good for pain......and the aggressiveness mentioned above. I think I'll stick with cymbalta if it comes down to it. You know, better off with the devil you know....

 
Bit of an outdated thread but there's been some info recently.
 
Forest, in their ongoing quest to abuse the everliving crap out of brand names and the patent system has been trying to get the active enantiomer of Savella (levomilnacipran) approved for depression. Back in 2012 they got a pretty sound thrashing by the FDA over abysmal efficacy in their studies, just really really bad results.
 
It looks like they've re-applied with a new study that shows better results. However, the study isn't as large as it should be: they used very severe depression as an inclusion criteria, using HDRS, SDS, but then used MADRS as a measure of outcome - which is pretty well known to be defective. The FDA CDER response is due out on 7/26.

And it's been approved. Say hello to the next "me too" drug.........Fetzima. Gotta love evergreening.

http://www.fiercebio...zima/2013-07-26

Edited by quiet storm, 04 August 2013 - 06:49 PM.

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#13 Serpens

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Posted 04 August 2013 - 08:34 PM

 

 

My doc mentioned savella to me today after discussing about possibly getting back on cymbalta, mainly for headaches, but secondarily for mood. I was a sweaty, jittery mess when I was on it but I got alot of shit done when I was on cymbalta. She mentioned savella and it was the first I've heard of it. Probably because its only approved for fibromyalgia in the US. It's classified as an SNRI but from what I've read it pushes the norepi about 3 times as much as serotonin. Probably why it's good for pain......and the aggressiveness mentioned above. I think I'll stick with cymbalta if it comes down to it. You know, better off with the devil you know....

 
Bit of an outdated thread but there's been some info recently.
 
Forest, in their ongoing quest to abuse the everliving crap out of brand names and the patent system has been trying to get the active enantiomer of Savella (levomilnacipran) approved for depression. Back in 2012 they got a pretty sound thrashing by the FDA over abysmal efficacy in their studies, just really really bad results.
 
It looks like they've re-applied with a new study that shows better results. However, the study isn't as large as it should be: they used very severe depression as an inclusion criteria, using HDRS, SDS, but then used MADRS as a measure of outcome - which is pretty well known to be defective. The FDA CDER response is due out on 7/26.

And it's been approved. Say hello to the next "me too" drug.........Fetzima. Gotta love evergreening.

http://www.fiercebio...zima/2013-07-26

 

 

Just god damned fucking lovely. Forest is one of the single worst offenders in evergreening, me-too garbage drugs, price gouging and excessively promoting brand name worship.


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#14 quiet storm

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Posted 05 August 2013 - 04:25 PM

You gotta wonder if Eli Lily wished they could go back and do cymbalta differently. Cymbalta was an enantiomer, and it was the more potent of the two. I'm no expert on pharmakinetics and stereoisomers but I wonder If they could've just marketed the original drug with both enantiomers for a decade and then evergreened the ole cymbalta for another.

Cymbaltas off patent come December. Dont think they have anything else in the pieline at the moment to make up for it. Kind of feel bad for ole Eli.....NOT. Not when it cost $250 for a 30 day supply without insurance. Eat a dick.
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